Human Two pore calcium channel protein 2 (TPCN2) activation kit by CRISPRa

CAT#: GA116532

TPCN2 CRISPRa kit - CRISPR gene activation of human two pore segment channel 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TPCN2
• Locus ID: 219931
• Kit Components:

  GA116532G1, TPCN2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116532G2, TPCN2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116532G3, TPCN2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_139075
• Synonyms: SHEP10; TPC2
• Summary: This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation. [provided by RefSeq, Dec 2009]