Human MARCH8 activation kit by CRISPRa

CAT#: GA116580

MARCH8 CRISPRa kit - CRISPR gene activation of human membrane associated ring-CH-type finger 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MARCH8
• Locus ID: 220972
• Kit Components:

  GA116580G1, MARCH8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116580G2, MARCH8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116580G3, MARCH8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001002265, NM_001002266, NM_001282866, NM_145021
• Synonyms: c-MIR; MARCH-VIII; MIR; RNF178
• Summary: MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]). [supplied by OMIM, Apr 2010]