Human UCMA activation kit by CRISPRa

CAT#: GA116587

UCMA CRISPRa kit - CRISPR gene activation of human upper zone of growth plate and cartilage matrix associated

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UCMA
• Locus ID: 221044
• Kit Components:

  GA116587G1, UCMA gRNA vector 1 in pCas-Guide-CRISPRa

  GA116587G2, UCMA gRNA vector 2 in pCas-Guide-CRISPRa

  GA116587G3, UCMA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303118, NM_001303119, NM_145314
• Synonyms: C10orf49; GRP; GRP/UCMA
• Summary: This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]