Human HIST1H2AA activation kit by CRISPRa

CAT#: GA116630

HIST1H2AA CRISPRa kit - CRISPR gene activation of human histone cluster 1 H2A family member a

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HIST1H2AA
• Locus ID: 221613
• Kit Components:

  GA116630G1, HIST1H2AA gRNA vector 1 in pCas-Guide-CRISPRa

  GA116630G2, HIST1H2AA gRNA vector 2 in pCas-Guide-CRISPRa

  GA116630G3, HIST1H2AA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_170745
• Synonyms: bA317E16.2; H2AA; H2AFR; TH2A
• Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]