Human BAAT1 (BRAT1) activation kit by CRISPRa

CAT#: GA116647

BRAT1 CRISPRa kit - CRISPR gene activation of human BRCA1 associated ATM activator 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BRAT1
• Locus ID: 221927
• Kit Components:

  GA116647G1, BRAT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116647G2, BRAT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116647G3, BRAT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_152743, NM_001350626, NM_001350627, NR_146879
• Synonyms: BAAT1; C7orf27; RMFSL
• Summary: The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]