Human AKR7L activation kit by CRISPRa

CAT#: GA116720

AKR7L CRISPRa kit - CRISPR gene activation of human aldo-keto reductase family 7 like (gene/pseudogene)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AKR7L
• Locus ID: 246181
• Kit Components:

  GA116720G1, AKR7L gRNA vector 1 in pCas-Guide-CRISPRa

  GA116720G2, AKR7L gRNA vector 2 in pCas-Guide-CRISPRa

  GA116720G3, AKR7L gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145289, NM_201252, NR_040288, NR_040289, NM_001348421
• Synonyms: AFAR3; AKR7A4
• Summary: This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017]