Human RNase H1 (RNASEH1) activation kit by CRISPRa

CAT#: GA116723

RNASEH1 CRISPRa kit - CRISPR gene activation of human ribonuclease H1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNASEH1
• Locus ID: 246243
• Kit Components:

  GA116723G1, RNASEH1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116723G2, RNASEH1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116723G3, RNASEH1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286834, NM_001286837, NM_002936, NR_148532, NR_148533, NR_148534
• Synonyms: H1RNA; RNH1
• Summary: This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017]