Human PCSK9 activation kit by CRISPRa

CAT#: GA116832

PCSK9 CRISPRa kit - CRISPR gene activation of human proprotein convertase subtilisin/kexin type 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PCSK9
• Locus ID: 255738
• Kit Components:

  GA116832G1, PCSK9 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116832G2, PCSK9 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116832G3, PCSK9 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_174936, NR_110451
• Synonyms: FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9
• Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]