Human PTF1A activation kit by CRISPRa

CAT#: GA116854

PTF1A CRISPRa kit - CRISPR gene activation of human pancreas associated transcription factor 1a

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTF1A
• Locus ID: 256297
• Kit Components:

  GA116854G1, PTF1A gRNA vector 1 in pCas-Guide-CRISPRa

  GA116854G2, PTF1A gRNA vector 2 in pCas-Guide-CRISPRa

  GA116854G3, PTF1A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_178161
• Synonyms: bHLHa29; PACA; PAGEN2; PTF1-p48
• Summary: This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]