Human TAB3 activation kit by CRISPRa

CAT#: GA116898

TAB3 CRISPRa kit - CRISPR gene activation of human TGF-beta activated kinase 1 (MAP3K7) binding protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TAB3
• Locus ID: 257397
• Kit Components:

  GA116898G1, TAB3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116898G2, TAB3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116898G3, TAB3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_152787, NM_198312
• Synonyms: MAP3K7IP3; NAP1
• Summary: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]