Human VGCNL1 (NALCN) activation kit by CRISPRa

CAT#: GA116908

NALCN CRISPRa kit - CRISPR gene activation of human sodium leak channel, non-selective

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NALCN
• Locus ID: 259232
• Kit Components:

  GA116908G1, NALCN gRNA vector 1 in pCas-Guide-CRISPRa

  GA116908G2, NALCN gRNA vector 2 in pCas-Guide-CRISPRa

  GA116908G3, NALCN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_052867, NM_001350748, NM_001350749, NM_001350750, NM_001350751
• Synonyms: bA430M15.1; CanIon; CLIFAHDD; IHPRF; INNFD; VGCNL1
• Summary: This gene encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodium leak current that contributes to tonic neuronal excitability. The encoded protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in this gene are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth. [provided by RefSeq, Apr 2017]