Human AER61 (EOGT) activation kit by CRISPRa

CAT#: GA117201

EOGT CRISPRa kit - CRISPR gene activation of human EGF domain specific O-linked N-acetylglucosamine transferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EOGT
• Locus ID: 285203
• Kit Components:

  GA117201G1, EOGT gRNA vector 1 in pCas-Guide-CRISPRa

  GA117201G2, EOGT gRNA vector 2 in pCas-Guide-CRISPRa

  GA117201G3, EOGT gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278689, NM_173654, NR_103826
• Synonyms: AER61; AOS4; C3orf64; EOGT1
• Summary: This gene encodes an enzyme that acts in the lumen of the endoplasmic reticulum to catalyze the transfer of N-acetylglucosamine to serine or threonine residues of extracellular-targeted proteins. This enzyme modifies proteins containing eukaryotic growth factor (EGF)-like domains, including the Notch receptor, thereby regulating developmental signalling. Mutations in this gene have been observed in individuals with Adams-Oliver syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]