Human NLRP10 activation kit by CRISPRa

CAT#: GA117363

NLRP10 CRISPRa kit - CRISPR gene activation of human NLR family pyrin domain containing 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NLRP10
• Locus ID: 338322
• Kit Components:

  GA117363G1, NLRP10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA117363G2, NLRP10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA117363G3, NLRP10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_176821
• Synonyms: CLR11.1; NALP10; NOD8; PAN5; PYNOD
• Summary: Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]