Human FAM5C (BRINP3) activation kit by CRISPRa

CAT#: GA117428

BRINP3 CRISPRa kit - CRISPR gene activation of human BMP/retinoic acid inducible neural specific 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BRINP3
• Locus ID: 339479
• Kit Components:

  GA117428G1, BRINP3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA117428G2, BRINP3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA117428G3, BRINP3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317188, NM_199051
• Synonyms: DBCCR1L; DBCCR1L1; FAM5C
• Summary: This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]