Human STING (TMEM173) activation kit by CRISPRa

CAT#: GA117456

TMEM173 CRISPRa kit - CRISPR gene activation of human transmembrane protein 173

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMEM173
• Locus ID: 340061
• Kit Components:

  GA117456G1, TMEM173 gRNA vector 1 in pCas-Guide-CRISPRa

  GA117456G2, TMEM173 gRNA vector 2 in pCas-Guide-CRISPRa

  GA117456G3, TMEM173 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301738, NM_198282, NM_001367258
• Synonyms: ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING
• Summary: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]