Human MACC1 activation kit by CRISPRa

CAT#: GA117625

MACC1 CRISPRa kit - CRISPR gene activation of human MET transcriptional regulator MACC1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MACC1
• Locus ID: 346389
• Kit Components:

  GA117625G1, MACC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA117625G2, MACC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA117625G3, MACC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_182762
• Synonyms: 7A5; SH3BP4L
• Summary: MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]). [supplied by OMIM, Mar 2009]