Human QRFP activation kit by CRISPRa

CAT#: GA117637

QRFP CRISPRa kit - CRISPR gene activation of human pyroglutamylated RFamide peptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: QRFP
• Locus ID: 347148
• Kit Components:

  GA117637G1, QRFP gRNA vector 1 in pCas-Guide-CRISPRa

  GA117637G2, QRFP gRNA vector 2 in pCas-Guide-CRISPRa

  GA117637G3, QRFP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_198180
• Synonyms: 26RFa; P518
• Summary: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]