Human KIF7 activation kit by CRISPRa

CAT#: GA117772

KIF7 CRISPRa kit - CRISPR gene activation of human kinesin family member 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KIF7
• Locus ID: 374654
• Kit Components:

  GA117772G1, KIF7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA117772G2, KIF7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA117772G3, KIF7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_198525
• Synonyms: ACLS; AGBK; HLS2; JBTS12; UNQ340
• Summary: This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011]