Human Agrin (AGRN) activation kit by CRISPRa

CAT#: GA117836

AGRN CRISPRa kit - CRISPR gene activation of human agrin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AGRN
• Locus ID: 375790
• Kit Components:

  GA117836G1, AGRN gRNA vector 1 in pCas-Guide-CRISPRa

  GA117836G2, AGRN gRNA vector 2 in pCas-Guide-CRISPRa

  GA117836G3, AGRN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001305275, NM_198576, NM_001364727
• Synonyms: CMS8; CMSPPD
• Summary: This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]