Human FLG2 activation kit by CRISPRa

CAT#: GA117991

FLG2 CRISPRa kit - CRISPR gene activation of human filaggrin family member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FLG2
• Locus ID: 388698
• Kit Components:

  GA117991G1, FLG2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA117991G2, FLG2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA117991G3, FLG2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001014342
• Synonyms: IFPS
• Summary: The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015]