Human LIN28B activation kit by CRISPRa

CAT#: GA118054

LIN28B CRISPRa kit - CRISPR gene activation of human lin-28 homolog B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LIN28B
• Locus ID: 389421
• Kit Components:

  GA118054G1, LIN28B gRNA vector 1 in pCas-Guide-CRISPRa

  GA118054G2, LIN28B gRNA vector 2 in pCas-Guide-CRISPRa

  GA118054G3, LIN28B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001004317
• Synonyms: CSDD2
• Summary: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]