Human GCN2 (EIF2AK4) activation kit by CRISPRa

CAT#: GA118447

EIF2AK4 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 2 alpha kinase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EIF2AK4
• Locus ID: 440275
• Kit Components:

  GA118447G1, EIF2AK4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA118447G2, EIF2AK4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA118447G3, EIF2AK4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001013703
• Synonyms: GCN2; PVOD2
• Summary: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]