Human SPINK9 activation kit by CRISPRa

CAT#: GA118693

SPINK9 CRISPRa kit - CRISPR gene activation of human serine peptidase inhibitor, Kazal type 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPINK9
• Locus ID: 643394
• Kit Components:

  GA118693G1, SPINK9 gRNA vector 1 in pCas-Guide-CRISPRa

  GA118693G2, SPINK9 gRNA vector 2 in pCas-Guide-CRISPRa

  GA118693G3, SPINK9 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040433
• Synonyms: LEKTI2
• Summary: The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015]