Human PGA3 activation kit by CRISPRa

CAT#: GA118708

PGA3 CRISPRa kit - CRISPR gene activation of human pepsinogen 3, group I (pepsinogen A)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PGA3
• Locus ID: 643834
• Kit Components:

  GA118708G1, PGA3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA118708G2, PGA3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA118708G3, PGA3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001079807
• Synonyms: PGA4; PGA5
• Summary: This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]