Human Caspase 12 (CASP12) activation kit by CRISPRa

CAT#: GA119308

CASP12 CRISPRa kit - CRISPR gene activation of human caspase 12 (gene/pseudogene)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CASP12
• Locus ID: 100506742
• Kit Components:

  GA119308G1, CASP12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA119308G2, CASP12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA119308G3, CASP12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001191016, NR_034061, NR_034063, NR_034064, NR_034065, NR_034066, NR_034067, NR_034068, NR_034070, NR_034071
• Synonyms: CASP-12; CASP12P1
• Summary: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]