Mouse Aanat activation kit by CRISPRa

CAT#: GA200002

Aanat CRISPRa kit - CRISPR gene activation of mouse arylalkylamine N-acetyltransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Aanat
• Locus ID: 11298
• Kit Components:

  GA200002G1, Aanat gRNA vector 1 in pCas-Guide-CRISPRa

  GA200002G2, Aanat gRNA vector 2 in pCas-Guide-CRISPRa

  GA200002G3, Aanat gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009591, NR_033223
• Synonyms: AA-NAT; Nat-2; Nat4; Snat
• Summary: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]