Mouse Adam12 activation kit by CRISPRa

CAT#: GA200061

Adam12 CRISPRa kit - CRISPR gene activation of mouse a disintegrin and metallopeptidase domain 12 (meltrin alpha)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Adam12
• Locus ID: 11489
• Kit Components:

  GA200061G1, Adam12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200061G2, Adam12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200061G3, Adam12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007400
• Synonyms: Mltna
• Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein that localizes to the cell surface. About a third of the mice lacking the encoded protein die before weaning. Overexpression of the encoded protein in a mouse model of Duchenne muscular dystrophy alleviates the muscle pathology by preventing cell necrosis and inflammation. [provided by RefSeq, May 2016]