Mouse Adam17 activation kit by CRISPRa

CAT#: GA200063

Adam17 CRISPRa kit - CRISPR gene activation of mouse a disintegrin and metallopeptidase domain 17

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Adam17
• Locus ID: 11491
• Kit Components:

  GA200063G1, Adam17 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200063G2, Adam17 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200063G3, Adam17 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001277266, NM_001291871, NM_009615, NR_102380, NR_120376
• Synonyms: CD156b; Tace
• Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]