Mouse Parp2 activation kit by CRISPRa

CAT#: GA200097

Parp2 CRISPRa kit - CRISPR gene activation of mouse poly (ADP-ribose) polymerase family, member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Parp2
• Locus ID: 11546
• Kit Components:

  GA200097G1, Parp2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200097G2, Parp2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200097G3, Parp2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009632
• Synonyms: Adprt2; Adprtl2; ARTD2; Aspartl2; C78626; PARP-2
• Summary: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. [UniProtKB/Swiss-Prot Function]