Mouse Nr0b1 activation kit by CRISPRa

CAT#: GA200131

Nr0b1 CRISPRa kit - CRISPR gene activation of mouse nuclear receptor subfamily 0, group B, member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Nr0b1
• Locus ID: 11614
• Kit Components:

  GA200131G1, Nr0b1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200131G2, Nr0b1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200131G3, Nr0b1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007430
• Synonyms: Ahc; Ahch; AHX; DAX-1; Dax1
• Summary: This gene encodes an orphan nuclear receptor protein that plays a key role in differentiation of the gonads. This protein regulates steroidogenic factor 1 (Sf-1) in a dose-dependent manner, sometimes functioning as a repressor of SF-1 target genes, and sometimes functioning as a co-activator. Overexpression of this gene can cause feminization of the XY male gonads. This gene is also involved in the maintenance of embryonic stem cell pluripotancy. Mutations in the related gene in human cause congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, May 2015]