Mouse Alox8 activation kit by CRISPRa

CAT#: GA200169

Alox8 CRISPRa kit - CRISPR gene activation of mouse arachidonate 8-lipoxygenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Alox8
• Locus ID: 11688
• Kit Components:

  GA200169G1, Alox8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200169G2, Alox8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200169G3, Alox8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009661
• Synonyms: 8-LOX; 8S-LOX; 15-LOX-2; 15-LOX-B; Alox15b
• Summary: This gene belongs to the lipoxygenase (LOX) gene family whose members encode enzymes that catalyze the addition of molecular oxygen to polyunsaturated fatty acids (PUFAs) to yield fatty acid hydroperoxides. The encoded enzyme preferentially metabolizes arachidonic acid to yield 8-hydroxyeicosatetraenoic acid (8-HETE), while metabolizing linoleic acid less efficiently. The gene may also function as a tumor suppressor. This gene is located in a cluster of related genes that spans approximately 75 kilobases on chromosome 11. [provided by RefSeq, Jan 2013]