Mouse Ap1m1 activation kit by CRISPRa

CAT#: GA200206

Ap1m1 CRISPRa kit - CRISPR gene activation of mouse adaptor-related protein complex AP-1, mu subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ap1m1
• Locus ID: 11767
• Kit Components:

  GA200206G1, Ap1m1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200206G2, Ap1m1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200206G3, Ap1m1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007456
• Synonyms: AA408894; Adtm1A; AP47; Cltnm; mu1A
• Summary: This gene encodes the mu-1 subunit of the scaffolding adapter protein complex AP-1 and is a member of the mu adaptin family. The AP-1 complex, which consists of 4 subunits (mu-adaptin, beta-prime adaptin, gamma-adaptin, and the small chain adaptin), is one of the predominant coat proteins of membrane vesicles involved in eukaryotic post-Golgi trafficking. The AP-1 complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. AP-1 complex subunit mu-1 and other mu-adaptins select cargo proteins bearing sequence-specific sorting motifs. [provided by RefSeq, Jul 2016]