Mouse Ap4s1 activation kit by CRISPRa

CAT#: GA200219

Ap4s1 CRISPRa kit - CRISPR gene activation of mouse adaptor-related protein complex AP-4, sigma 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ap4s1
• Locus ID: 11782
• Kit Components:

  GA200219G1, Ap4s1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200219G2, Ap4s1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200219G3, Ap4s1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001329698, NM_001329699, NM_021710
• Synonyms: AI314282
• Summary: This gene encodes the sigma subunit of the adaptor-related protein complex 4 which mediates intracellular membrane trafficking along the endocytic and secretory transport pathways. This complex contains four subunits, beta, epsilon, mu, and sigma, and belongs to a family of five adapter protein complexes, including three clathrin-associated complexes and two non clathrin-associated complexes, that localize to different intracellular compartments and mediate membrane vesicle trafficking using distinct pathways. In humans, loss-of-function mutations in this gene have been linked to specific adapter complex 4 deficiency disorders including hereditary spastic paraplegia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]