Mouse Xiap activation kit by CRISPRa

CAT#: GA200230

Xiap CRISPRa kit - CRISPR gene activation of mouse X-linked inhibitor of apoptosis

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Xiap
• Locus ID: 11798
• Kit Components:

  GA200230G1, Xiap gRNA vector 1 in pCas-Guide-CRISPRa

  GA200230G2, Xiap gRNA vector 2 in pCas-Guide-CRISPRa

  GA200230G3, Xiap gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301639, NM_001301641, NM_009688, NR_125870
• Synonyms: 1110015C02Rik; Aipa; Api3; Birc4; IAP3; ILP-1; MIHA
• Summary: The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]