Mouse Aplp1 activation kit by CRISPRa

CAT#: GA200234

Aplp1 CRISPRa kit - CRISPR gene activation of mouse amyloid beta (A4) precursor-like protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Aplp1
• Locus ID: 11803
• Kit Components:

  GA200234G1, Aplp1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200234G2, Aplp1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200234G3, Aplp1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007467
• Summary: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. [UniProtKB/Swiss-Prot Function]