Mouse Apoe activation kit by CRISPRa

CAT#: GA200245

Apoe CRISPRa kit - CRISPR gene activation of mouse apolipoprotein E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Apoe
• Locus ID: 11816
• Kit Components:

  GA200245G1, Apoe gRNA vector 1 in pCas-Guide-CRISPRa

  GA200245G2, Apoe gRNA vector 2 in pCas-Guide-CRISPRa

  GA200245G3, Apoe gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001305819, NM_001305843, NM_001305844, NM_009696
• Synonyms: AI255918; Apo-E
• Summary: This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]