Mouse Asgr1 activation kit by CRISPRa

CAT#: GA200296

Asgr1 CRISPRa kit - CRISPR gene activation of mouse asialoglycoprotein receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Asgr1
• Locus ID: 11889
• Kit Components:

  GA200296G1, Asgr1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200296G2, Asgr1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200296G3, Asgr1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291131, NM_001291132, NM_009714
• Synonyms: ASGPR1; Asgr; Asgr-1; HL-1
• Summary: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. [UniProtKB/Swiss-Prot Function]