Mouse Atpif1 activation kit by CRISPRa

CAT#: GA200343

Atpif1 CRISPRa kit - CRISPR gene activation of mouse ATPase inhibitory factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Atpif1
• Locus ID: 11983
• Kit Components:

  GA200343G1, Atpif1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200343G2, Atpif1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200343G3, Atpif1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007512
• Synonyms: Atpi; IF(1); If1
• Summary: This gene encodes a member of the ATPase inhibitor family of proteins. This protein has been shown to negatively regulate the ATP hydrolysis activity of the F1Fo-ATPase. Knockdown of this gene is associated with reduced heme synthesis in differentiating erythroid cells. Misregulation of this gene has been found to lead to increased aerobic glycolysis in mouse cancer cells, while high expression levels of this gene have been correlated with gastric and liver cancer severity in human patients. A pseudogene of this gene has been identified. [provided by RefSeq, Apr 2015]