Mouse Bag1 activation kit by CRISPRa

CAT#: GA200365

Bag1 CRISPRa kit - CRISPR gene activation of mouse BCL2-associated athanogene 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bag1
• Locus ID: 12017
• Kit Components:

  GA200365G1, Bag1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200365G2, Bag1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200365G3, Bag1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001171739, NM_009736
• Synonyms: BAG-1; Rap46
• Summary: The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]