Mouse Bcl2 activation kit by CRISPRa

CAT#: GA200382

Bcl2 CRISPRa kit - CRISPR gene activation of mouse B cell leukemia/lymphoma 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bcl2
• Locus ID: 12043
• Kit Components:

  GA200382G1, Bcl2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200382G2, Bcl2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200382G3, Bcl2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009741, NM_177410
• Synonyms: AW986256; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik
• Summary: This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]