Mouse Bcl2l1 activation kit by CRISPRa

CAT#: GA200387

Bcl2l1 CRISPRa kit - CRISPR gene activation of mouse BCL2-like 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bcl2l1
• Locus ID: 12048
• Kit Components:

  GA200387G1, Bcl2l1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200387G2, Bcl2l1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200387G3, Bcl2l1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001289716, NM_001289717, NM_001289739, NM_009743, NR_149254, NM_001355053
• Synonyms: Bcl(X)L; bcl-x; Bcl-XL; bcl2-L-1; Bcl2l; BclX
• Summary: This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]