Mouse Bglap activation kit by CRISPRa

CAT#: GA200402

Bglap CRISPRa kit - CRISPR gene activation of mouse bone gamma carboxyglutamate protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bglap
• Locus ID: 12096
• Kit Components:

  GA200402G1, Bglap gRNA vector 1 in pCas-Guide-CRISPRa

  GA200402G2, Bglap gRNA vector 2 in pCas-Guide-CRISPRa

  GA200402G3, Bglap gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037939, NM_007541
• Synonyms: Bglap1; mOC-A; OC; OG1
• Summary: This gene encodes one of the most abundant non-collagenous proteins in bone tissue that is localized to the mineralized matrix of bone. The encoded preproprotein undergoes proteolytic processing and post-translational gamma carboxylation to generate a mature, calcium-binding protein. Mice lacking the encoded protein develop abnormalities of bone remodelling. This gene is located adjacent to two other osteocalcin-related genes on chromosome 3. [provided by RefSeq, Oct 2015]