Mouse Bmp2 activation kit by CRISPRa

CAT#: GA200418

Bmp2 CRISPRa kit - CRISPR gene activation of mouse bone morphogenetic protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bmp2
• Locus ID: 12156
• Kit Components:

  GA200418G1, Bmp2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200418G2, Bmp2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200418G3, Bmp2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007553
• Synonyms: AI467020; Bmp2a
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. While a homozygous knockout mouse for this gene exhibits embryonic lethality, conditional knockout mice have defects in bone, cartilage and heart development. [provided by RefSeq, Jul 2016]