Mouse Bmp4 activation kit by CRISPRa

CAT#: GA200419

Bmp4 CRISPRa kit - CRISPR gene activation of mouse bone morphogenetic protein 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bmp4
• Locus ID: 12159
• Kit Components:

  GA200419G1, Bmp4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200419G2, Bmp4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200419G3, Bmp4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001316360, NM_007554
• Synonyms: Bmp-4; Bmp2b; Bmp2b-1; Bmp2b1
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]