Mouse Bmp6 activation kit by CRISPRa

CAT#: GA200421

Bmp6 CRISPRa kit - CRISPR gene activation of mouse bone morphogenetic protein 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bmp6
• Locus ID: 12161
• Kit Components:

  GA200421G1, Bmp6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200421G2, Bmp6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200421G3, Bmp6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007556
• Synonyms: D13Wsu115e; Vgr1
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females. [provided by RefSeq, Jul 2016]