Mouse Bmpr2 activation kit by CRISPRa

CAT#: GA200428

Bmpr2 CRISPRa kit - CRISPR gene activation of mouse bone morphogenetic protein receptor, type II (serine/threonine kinase)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Bmpr2
• Locus ID: 12168
• Kit Components:

  GA200428G1, Bmpr2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200428G2, Bmpr2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200428G3, Bmpr2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007561
• Synonyms: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPRII; BRK-3; Gm20272
• Summary: This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]