Mouse C1qc activation kit by CRISPRa

CAT#: GA200462

C1qc CRISPRa kit - CRISPR gene activation of mouse complement component 1, q subcomponent, C chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: C1qc
• Locus ID: 12262
• Kit Components:

  GA200462G1, C1qc gRNA vector 1 in pCas-Guide-CRISPRa

  GA200462G2, C1qc gRNA vector 2 in pCas-Guide-CRISPRa

  GA200462G3, C1qc gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007574
• Synonyms: AI385742; C1qg; Ciqc
• Summary: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [UniProtKB/Swiss-Prot Function]