Mouse Ciita activation kit by CRISPRa

CAT#: GA200464

Ciita CRISPRa kit - CRISPR gene activation of mouse class II transactivator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ciita
• Locus ID: 12265
• Kit Components:

  GA200464G1, Ciita gRNA vector 1 in pCas-Guide-CRISPRa

  GA200464G2, Ciita gRNA vector 2 in pCas-Guide-CRISPRa

  GA200464G3, Ciita gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243760, NM_001243761, NM_001302618, NM_001302619, NM_007575
• Synonyms: C2ta; EG669998; Gm9475; Mhc2ta
• Summary: This gene encodes a member of the NOD-like receptor protein family. This protein acts as a transcriptional coactivator and component of the enhanceosome complex to stimulate transcription of MHC class II genes in the adaptive immune response. This protein may also regulate the transcription of MHC class I genes. Mutations in the human gene have been linked to a rare immunodeficiency, bare lymphocyte syndrome, and homozygous knockout mice exhibit many features of this disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]