Mouse Cacna1b activation kit by CRISPRa

CAT#: GA200476

Cacna1b CRISPRa kit - CRISPR gene activation of mouse calcium channel, voltage-dependent, N type, alpha 1B subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cacna1b
• Locus ID: 12287
• Kit Components:

  GA200476G1, Cacna1b gRNA vector 1 in pCas-Guide-CRISPRa

  GA200476G2, Cacna1b gRNA vector 2 in pCas-Guide-CRISPRa

  GA200476G3, Cacna1b gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042528, NM_007579
• Synonyms: alpha(1B); AW050276; AW060892; AW822256; BIII; Cav2.2; Cchn1a
• Summary: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. [UniProtKB/Swiss-Prot Function]