Mouse Cacna1d activation kit by CRISPRa

CAT#: GA200478

Cacna1d CRISPRa kit - CRISPR gene activation of mouse calcium channel, voltage-dependent, L type, alpha 1D subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cacna1d
• Locus ID: 12289
• Kit Components:

  GA200478G1, Cacna1d gRNA vector 1 in pCas-Guide-CRISPRa

  GA200478G2, Cacna1d gRNA vector 2 in pCas-Guide-CRISPRa

  GA200478G3, Cacna1d gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001083616, NM_001302637, NM_028981
• Synonyms: 8430418G19Rik; C79217; Cach3; Cacn4; Cacnl1a2; Cav1.3; Cchl1a; Cchl1a2; D-LTCC
• Summary: This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]